Over 1,000 rockets were launched by Palestinian militants, according to BBC.
Three tower blocks were destroyed in an Israeli response due to hundreds of airstrikes on Gaza.
65 Palestinians and six people in Israel are now dead including 16 Palestinian children.
UN Secretary-General António Guterres expressed that he is “gravely concerned.”
Israeli Prime Minister Benjamin Netanyahu and US Secretary of State Anthony Blinken shared a phone call where Blinken condemned Hamas attacks but expressed That Israel Is obligated to avoid civilian casualties.
The fighting began on Monday night after weeks of building tension.
Violent unrest has plagued towns with mixed populations of Jews and Arabs.
Tel Aviv is currently in a state of emergency.
Mr. Netanyahu expressed that the government would provide protection for Israel from enemies on the outside and rioters in the inside.
Palestinian Authority said Israel’s ‘military aggression” is “traumatizing an already beleaguered population of 2 million people”.
The Israeli prime minister said, “This was only the beginning. We will inflict blows on them that they have never dreamed of.”
Hamas confirmed the death of its commander and other “warriors.”
“Thousands of leaders and soldiers will follow in their footsteps,” Hamas said in a statement reported by Reuters news agency.
WATCH Israeli army targets Burj Al-Shurouq building in Gaza city during BBC Arabic’s producer Adnan Elbursh live report from the strip. pic.twitter.com/YwzBp90Mki
— Michael Shuval 🏳️🌈 (@MichaelShuval) May 12, 2021
11-year-old Yasmine said, “I had pain in my stomach from the fear and my parents were trying to comfort me and tell me the bombing was far away but I could feel that it was close.”
“Tomorrow is Eid and we won’t be celebrating because of this conflict.”
Millions of Israelis headed for bomb shelters on Wednesday night as air raid sirens wailed.
The conflict is the result of escalating clashes between Palestinians and Israeli police.
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Hamas said it was incensed by “the enemy’s targeting of residential towers”.
Residents had been warned to evacuate the buildings before fighter jets attacked; however health officials said there were still civilian deaths.
Five members of one family were killed in an air strike on Tuesday, including two young brothers, according to AFP news agency.
On Wednesday morning an Israeli soldier was killed by an anti-tank missile fired from Gaza into Israel, authorities said.
There were conflicting reports on the fate of a six-year-old boy hit in a rocket attack on the town of Sderot, with some saying he had died in the attack.
Two people, a man and his teenage daughter, were killed in Lod when a rocket hit their car. They were both Israeli Arabs.
Israeli police reported what they called violent riots in dozens of areas of the country overnight, with 270 people arrested.
Synagogues and businesses in Lod were set on fire.
Mr Netanyahu described the riots as “unbearable” and said they reminded the Jewish people of their past.
Israeli police said that Lod would be placed under curfew from 20:00 local time on Wednesday until 04:00 on Thursday to preserve the safety and property of residents.
The site is revered by both Muslims, who call it the Haram al-Sharif (Noble Sanctuary), and Jews, for whom it is known as the Temple Mount. Hamas demanded Israel remove police from there and the nearby predominantly Arab district of Sheikh Jarrah, where Palestinian families face eviction by Jewish settlers. Hamas launched rockets when its ultimatum went unheeded.
Palestinian anger had already been stoked by weeks of rising tension in East Jerusalem, inflamed by a series of confrontations with police since the start of the Islamic holy month of Ramadan in mid-April.